Multiple-unit Controlled Release Platform Formulation by Wruster Process

Evolution of an existing drug molecule from a conventional form to a novel delivery system can significantly improve its performance in terms of patient compliance, safety, and efficacy. Objective: The present investigation was undertaken to fabricate modified release tablet of metoprolol succinate using multiple unite pellets systems with Wruster process. Method: In the present study the effect of release modifier such xanthan gum, Carbomers, Eudragit, Kollidone SR, hydroxypropyl methylcellulose and Ethylcellulose was investigated. Drug loaded pellets was analysed using PXRD and FTIR spectroscopy. The in vitro drug dissolution study was carried out in pH 6.8 phosphate buffer employing paddle rotated at 50 rpm. The similarity factor (f2) was calculated for selection of best batch considering mean in vitro dissolution data of marketed formulation as a reference profile. Conclusion: It is concluded that the desired drug release pattern can be obtained by using a proper combination of HPMC and ethylcellulose.